Outcomes about the Gastrointestinal Tract and also other Smooth Muscle Codeine causes a discount in motility linked with an increase in clean muscle tone during the antrum from the abdomen and duodenum. Digestion of food items inside the modest intestine is delayed and propulsive contractions are diminished.
The subsequent really serious adverse reactions are explained, or described in bigger element, in other sections:
Reevaluate patients with unresponsive cough in 5 days or sooner for attainable fundamental pathology, including foreign physique or reduced respiratory tract illness.
Codeine may possibly enrich the neuromuscular blocking motion of skeletal muscle mass relaxants and deliver an increased degree of respiratory despair.
Although the risk of dependancy in any specific is mysterious, it may happen in sufferers appropriately prescribed Promethazine with Codeine Oral Solution. Habit can come about at encouraged dosages and Should the drug is misused or abused. Risks are elevated in sufferers with a personal or family record of material abuse (like drug or alcohol abuse or habit) or mental disease (e.g., main despair). Opioids are sought by drug abusers and people with dependancy Issues and so are subject matter to criminal diversion. Look at these dangers when prescribing or dispensing Promethazine with Codeine Oral Alternative. Approaches to lessen these hazards involve prescribing the drug in the smallest appropriate quantity and advising the client on the appropriate disposal of unused drug [see Individual COUNSELING Information and facts (seventeen)]. Get in touch with neighborhood condition Expert licensing board or point out managed substances authority for information on how to stop and detect abuse or diversion of the item.
Usually consult your Health care provider to be sure the information exhibited on this website page relates to your own situations.
If you're prescribed this medication on an everyday agenda and miss a dose, acquire it as soon as you keep in mind. If it is close to the time of the subsequent dose, skip the skipped dose. Choose your subsequent dose with the regular time. Don't double the dose to catch up.
Hemodialysis isn't routinely employed to enhance the elimination of codeine or promethazine from the human body.
Codeine has fantastic antitussive action, although fewer than that of morphine at equal doses. It truly is Employed in desire to morphine, for the reason that side effects are rare at the standard antitussive dose of codeine.
Never share opioid medication with Yet another particular person, especially another person with a history of drug abuse or addiction. MISUSE Might cause ADDICTION, OVERDOSE, OR DEATH. Continue to keep the more info medication in a location exactly where Other individuals cannot reach it. Selling or giving away opioid medicine is versus the legislation.
]. Promethazine Symptoms and signs or symptoms of overdosage with promethazine range from moderate depression of the central nervous technique and cardiovascular system to profound hypotension, respiratory despair, unconsciousness and sudden Demise.
Postmarketing circumstances of respiratory despair, such as fatalities, are reported with utilization of promethazine in pediatric clients. Concomitant administration with other respiratory depressants might raise the hazard of respiratory depression.
Everyday living-threatening respiratory depression and Dying have occurred in small children who been given codeine. Codeine is subject matter to variability in metabolism dependent upon CYP2D6 genotype (explained beneath), which can lead to an elevated publicity on the Energetic metabolite morphine. Primarily based on submit-internet marketing experiences, small children youthful than 12 many years aged seem like extra liable to the respiratory depressant results of codeine, particularly if you'll find threat factors for respiratory melancholy.
Don't flush prescription drugs down the rest room or pour them into a drain Except if instructed to take action. Properly discard this merchandise when it is actually expired or no longer necessary. Speak to your pharmacist or local waste disposal company.